A research-ready phenotype dataset
Harmonize authorized data sources into a documented schema. Map phenotype terms to the Human Phenotype Ontology and Mondo, preserving provenance, uncertainty, and review status.
DAYBREAKER HEALTH / INDEPENDENT RESEARCH
The EDS
Atlas Project
Better evidence for people living with Ehlers-Danlos syndrome.
An independent, noncommercial research initiative led by Daybreaker Health founder Lucas Chatham, combining phenotype data, evidence synthesis, and expert review.
Explore the research repositoryIndependent Ehlers-Danlos Research Collaborative
WHY THIS RESEARCH LIVES HERE
A founder’s contribution to lifelong health.
Lucas Chatham founded Daybreaker Health with a focus on health and longevity. Alongside that work, he leads the EDS Atlas Project as an independent, noncommercial contribution to research for public benefit.
This project extends his interest in lifelong health to people living with Ehlers-Danlos syndrome. Its purpose is to improve the evidence available for research, with plans to share open-source tools and other permitted outputs so others can build on the work.
Daybreaker Health hosts this page to connect its founder’s research role, project documentation, and contact information.
RESEARCH QUESTION
Understanding variation across EDS.
Can harmonized clinical, patient-reported, and literature-derived phenotype data reveal reproducible symptom clusters and mechanistic relationships across Ehlers-Danlos syndrome?
The project investigates this question while developing an explainable evidence navigator that connects findings to their sources. The planned pilot focuses on hypermobile EDS, including bleeding, wound healing, and perioperative considerations.
An explainable research navigator
Develop a prototype for exploring phenotype relationships and source evidence, and generating questions and hypotheses for expert review.
Human review at each stage
Evaluate AI-assisted extraction and ontology mapping against expert-reviewed samples. Document errors, uncertainty, and the evidence behind proposed findings.
PEOPLE & RESPONSIBILITIES
Research leadership.
Lucas Chatham BBA, CPT, CAFS
Founder, Daybreaker Health
Project Lead and Scientific Lead, EDS Atlas Project
Lucas originated the project and leads its coordination, data integration, software development, and research workflow. He contributes experience in data systems, applied biomechanics, and lived experience with hypermobile Ehlers-Danlos syndrome.
Confirmed collaborators in the public project plan
- Jennifer G. Andrews, PhD, MBA
University of Arizona College of Medicine, Tucson - Melissa A. Haendel, PhD
UNC School of Medicine, TISLab
Additional participation and final responsibilities are being established. Collaborators retain their own affiliations; those institutions are not represented as project sponsors.
PROJECT STATUS
Accepted for research support.
The project has been accepted into Anthropic’s AI for Science research program. The research award provides usage credits; workspace setup and credit allocation are being coordinated.
Project name: The EDS Atlas Project
Research group: Independent Ehlers-Danlos Research Collaborative
Proposal title: Mapping EDS Heterogeneity: A Research-Ready Dataset and Explainable Evidence Navigator
The public repository currently documents the research plan. Datasets, tools, and evaluation results are planned deliverables, subject to data access, ethics requirements, and expert review.
OPEN CONTRIBUTION & GOVERNANCE
Built for public benefit.
This is noncommercial research with an open-source contribution goal. Code and documentation are intended for public release under appropriate licenses. Data and derived outputs will be shared only where permissions allow. The repository’s licensing and data-sharing terms will govern reuse.
- Use public or otherwise authorized data with appropriate consent and governance.
- Obtain required ethics approval before collecting new human-subjects data.
- Keep restricted patient-level data out of public repositories.
- Preserve source evidence, uncertainty, and human-review status.
The navigator is a planned research prototype. It does not provide medical advice, diagnosis, or treatment.
DOCUMENTATION & CONTACT
Follow the work.
Public repository · Research plan
Research inquiries: lucas@daybreakerhealth.com
Updated September 11, 2026